DNA analyses can separate cell RNAs or mRNAs on gels and transfer gel-band contents to filters, where RNAs can hybridize to known RNA or cDNA sequences {Northern blotting}. Northern blotting compares mRNAs to cDNAs to study gene expression.
DNA analyses can separate DNA fragments on gels and transfer gel-band contents to filters, where DNA fragments can hybridize to known DNA sequences {Southern blotting}. Southern blotting can detect gene rearrangements that make antibodies and T-cell receptors. It can detect disease-caused gene rearrangements and deletions. It can detect related genes in organisms and homologous genes from different species. It can detect mRNA-splicing-caused intron removal and exon use. It can detect mRNA splicing to make alternative proteins. It can detect nested genes.
4-Genetics-Recombinant DNA-DNA Sequencing
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Date Modified: 2022.0225